Title : Effect of pinaverium and other calcium channel blockers on contraction of isolated gastric antral smooth muscle cells caused by gastrointestinal hormones.

Pub. Date : 1994

PMID : 8201843






5 Functional Relationships(s)
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1 This contractile effect was dependent upon extracellular calcium for gastrin and CCK-8 but not for motilin. Calcium cholecystokinin Oryctolagus cuniculus
2 Pinaverium inhibited both gastrin- and CCK-8-induced contractions with IC-50 values of 1 nM and it was much less potent in the inhibition of motilin-induced contractions (IC-50 = 25 nM). pinaverium cholecystokinin Oryctolagus cuniculus
3 The effect of pinaverium was equivalent to that of diltiazem in the inhibition of CCK-8- or gastrin-induced contractions. pinaverium cholecystokinin Oryctolagus cuniculus
4 The effect of pinaverium was equivalent to that of diltiazem in the inhibition of CCK-8- or gastrin-induced contractions. Diltiazem cholecystokinin Oryctolagus cuniculus
5 In conclusion, it appears that since Ca2+ antagonists pinaverium, diltiazem and nicardipine inhibited contraction of smooth muscle cells stimulated by gastrointestinal hormones, "L-type" calcium channels of the plasma membrane might also be regulated through occupation of gastrin or CCK receptors. Nicardipine cholecystokinin Oryctolagus cuniculus