Title : Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

Pub. Date : 1986 Apr 15

PMID : 3514607






1 Functional Relationships(s)
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1 Reconstitution, immunoinhibition, and induction studies with rat liver indicated that the forms designated P-450UT-A and P-450PCN-E are the major contributors to microsomal nifedipine oxidation. Nifedipine cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus