Pub. Date : 2021 Jun 28
PMID : 34060475
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice. | Dihydrotestosterone | SREBF chaperone | Mus musculus |
| 2 | DHT mice displayed increased SCAP protein expression and SCAP-SREBP1 binding compared to controls. | Dihydrotestosterone | SREBF chaperone | Mus musculus |
| 3 | DHT mice displayed increased SCAP protein expression and SCAP-SREBP1 binding compared to controls. | Dihydrotestosterone | SREBF chaperone | Mus musculus |
| 4 | DHT mice exhibited increased AR binding to intron-8 of SCAP leading to increased SCAP mRNA compared to controls. | Dihydrotestosterone | SREBF chaperone | Mus musculus |
| 5 | DHT mice exhibited increased AR binding to intron-8 of SCAP leading to increased SCAP mRNA compared to controls. | Dihydrotestosterone | SREBF chaperone | Mus musculus |
| 6 | We show that in the presence of DHT the SCAP-SREBP1 interaction was elevated leading to increased nuclear SREBP1 resulting in increased de novo lipogenesis. | Dihydrotestosterone | SREBF chaperone | Mus musculus |