Title : Hyperphosphatemia in chronic kidney disease exacerbates atherosclerosis via a mannosidases-mediated complex-type conversion of SCAP N-glycans.

Pub. Date : 2021 Jun

PMID : 33631226






5 Functional Relationships(s)
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Protein Name
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1 Excess phosphate in vitro raised the activity of alpha-mannosidase, resulting in delayed SCAP degradation through promoting complex-type conversion of SCAP N-glycans. Phosphates SREBF chaperone Mus musculus
2 Excess phosphate in vitro raised the activity of alpha-mannosidase, resulting in delayed SCAP degradation through promoting complex-type conversion of SCAP N-glycans. Phosphates SREBF chaperone Mus musculus
3 Excess phosphate in vitro raised the activity of alpha-mannosidase, resulting in delayed SCAP degradation through promoting complex-type conversion of SCAP N-glycans. n-glycans SREBF chaperone Mus musculus
4 Excess phosphate in vitro raised the activity of alpha-mannosidase, resulting in delayed SCAP degradation through promoting complex-type conversion of SCAP N-glycans. n-glycans SREBF chaperone Mus musculus
5 The retention of SCAP enhanced transactivation of SREBP2 and expression of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, boosting intracellular cholesterol synthesis. Cholesterol SREBF chaperone Mus musculus