Title : MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice.

Pub. Date : 2020 Feb

PMID : 31852219






4 Functional Relationships(s)
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1 As a molecular mechanism, we identify the oxysterol metabolizing enzyme CYP7B1 (cytochrome P450 enzyme 7B1) as a miR-144 regulated gene in male, but not female mice. arthrofactin cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus
2 As a molecular mechanism, we identify the oxysterol metabolizing enzyme CYP7B1 (cytochrome P450 enzyme 7B1) as a miR-144 regulated gene in male, but not female mice. arthrofactin cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus
3 Consistent with miR-144-dependent changes in CYP7B1 activity, we show decreased levels of 27-hydroxycholesterol, a known proatherogenic sterol and the endogenous substrate for CYP7B1 in male, but not female mice. Sterols cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus
4 Consistent with miR-144-dependent changes in CYP7B1 activity, we show decreased levels of 27-hydroxycholesterol, a known proatherogenic sterol and the endogenous substrate for CYP7B1 in male, but not female mice. Sterols cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus