Title : Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms.

Pub. Date : 2019 Jun 21

PMID : 31082191






2 Functional Relationships(s)
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1 Overexpression of human DNA polymerase kappa (hpol kappa) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors. Temozolomide DNA polymerase kappa Homo sapiens
2 Overexpression of human DNA polymerase kappa (hpol kappa) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors. Temozolomide DNA polymerase kappa Homo sapiens