Title : Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner.

Pub. Date : 2018 Aug

PMID : 29943110






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In Shp-/- mice, APAP-evoked GADD45beta induction was significantly enhanced. Acetaminophen growth arrest and DNA-damage-inducible 45 beta Mus musculus
2 The current study is the first to demonstrate that hepatocyte-specific SHP deficiency protects against APAP overdose-evoked hepatotoxicity in a JNK signaling regulation and GADD45beta dependent manner. Acetaminophen growth arrest and DNA-damage-inducible 45 beta Mus musculus