Pub. Date : 2017 Nov
PMID : 28701330
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Various disorders including pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI), which are caused by inactivating mutations in ABCC6 and ENPP1, respectively, present with extensive tissue calcification due to reduced plasma pyrophosphate (PPi). | diphosphoric acid | ectonucleotide pyrophosphatase/phosphodiesterase 1 | Mus musculus |
| 2 | Noticeably, provision of drinking water with 0.3 mM PPi to mice heterozygous for inactivating mutations in Enpp1 during pregnancy robustly inhibited ectopic calcification in their Enpp1-/- offspring. | Water | ectonucleotide pyrophosphatase/phosphodiesterase 1 | Mus musculus |
| 3 | Noticeably, provision of drinking water with 0.3 mM PPi to mice heterozygous for inactivating mutations in Enpp1 during pregnancy robustly inhibited ectopic calcification in their Enpp1-/- offspring. | Water | ectonucleotide pyrophosphatase/phosphodiesterase 1 | Mus musculus |