Pub. Date : 2017 Jun 2
PMID : 28578430
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maintaining of cholesterol homeostasis in the rat spinal cord: 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) during the course of disease. | Cholesterol | cytochrome P450, family 46, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maintaining of cholesterol homeostasis in the rat spinal cord: 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) during the course of disease. | Cholesterol | cytochrome P450, family 46, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | Since CYP46A1 is responsible for removal of cholesterol excess, we performed a detailed profiling of CYP46A1 expression and revealed regional and temporal specificities in its distribution. | Cholesterol | cytochrome P450, family 46, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | Since CYP46A1 is responsible for removal of cholesterol excess, we performed a detailed profiling of CYP46A1 expression and revealed regional and temporal specificities in its distribution. | Cholesterol | cytochrome P450, family 46, subfamily a, polypeptide 1 | Rattus norvegicus |
| 5 | Double immunofluorescence staining demonstrated CYP46A1 localization with neurons, infiltrated macrophages, microglia and astrocytes in the areas of demyelination, suggesting that these cells play a role in cholesterol turnover in EAE. | Cholesterol | cytochrome P450, family 46, subfamily a, polypeptide 1 | Rattus norvegicus |