Pub. Date : 2015 Aug
PMID : 25896350
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SREBP cleavage-activating protein (Scap) is an endoplasmic reticulum membrane protein required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs), which activate the transcription of genes in sterol and fatty acid biosynthesis. | Sterols | SREBF chaperone | Mus musculus |
| 2 | SREBP cleavage-activating protein (Scap) is an endoplasmic reticulum membrane protein required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs), which activate the transcription of genes in sterol and fatty acid biosynthesis. | Sterols | SREBF chaperone | Mus musculus |
| 3 | SREBP cleavage-activating protein (Scap) is an endoplasmic reticulum membrane protein required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs), which activate the transcription of genes in sterol and fatty acid biosynthesis. | Fatty Acids | SREBF chaperone | Mus musculus |
| 4 | SREBP cleavage-activating protein (Scap) is an endoplasmic reticulum membrane protein required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs), which activate the transcription of genes in sterol and fatty acid biosynthesis. | Fatty Acids | SREBF chaperone | Mus musculus |
| 5 | Liver-specific loss of Scap is well tolerated; hepatic synthesis of sterols and fatty acids is reduced, but mice are otherwise healthy. | Sterols | SREBF chaperone | Mus musculus |
| 6 | Liver-specific loss of Scap is well tolerated; hepatic synthesis of sterols and fatty acids is reduced, but mice are otherwise healthy. | Fatty Acids | SREBF chaperone | Mus musculus |
| 7 | After 4 days of tamoxifen, Vil-Scap(-) mice succumb with a severe enteropathy and near-complete collapse of intestinal mucosa. | Tamoxifen | SREBF chaperone | Mus musculus |
| 8 | Organoids grown ex vivo from intestinal crypts of Vil-Scap(-) mice are readily killed when Scap is deleted by 4-hydroxytamoxifen. | hydroxytamoxifen | SREBF chaperone | Mus musculus |