Pub. Date : 2014 May 16
PMID : 24631677
20 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells. | Dopamine | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 2 | Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells. | Reactive Oxygen Species | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 3 | Together, these observations prompted us to investigate whether dopamine can regulate PIMT expression in SH-SY5Y neuroblastoma cells. | Dopamine | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 4 | Here, we report that dopamine down-regulated PIMT at both gene and protein levels. | Dopamine | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 5 | The same inhibition of PIMT protein level was caused by the electron transport chain inhibitor, rotenone, which was accompanied, in both cases, by an increase in cell death and reactive oxygen species (ROS) production. | Rotenone | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 6 | The same inhibition of PIMT protein level was caused by the electron transport chain inhibitor, rotenone, which was accompanied, in both cases, by an increase in cell death and reactive oxygen species (ROS) production. | Reactive Oxygen Species | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 7 | The same inhibition of PIMT protein level was caused by the electron transport chain inhibitor, rotenone, which was accompanied, in both cases, by an increase in cell death and reactive oxygen species (ROS) production. | Reactive Oxygen Species | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 8 | In fact, pre-treatment with the antioxidant N-acetyl cysteine blocked PIMT dopamine-associated down-regulation. | Acetylcysteine | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 9 | In fact, pre-treatment with the antioxidant N-acetyl cysteine blocked PIMT dopamine-associated down-regulation. | Dopamine | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 10 | The inhibition of PCMT1 promoter activity was mediated by dopamine-induced ROS since it was prevented by the hydroxyl radical scavenger N,N"-dimethylthiourea. | Dopamine | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 11 | The inhibition of PCMT1 promoter activity was mediated by dopamine-induced ROS since it was prevented by the hydroxyl radical scavenger N,N"-dimethylthiourea. | Reactive Oxygen Species | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 12 | The inhibition of PCMT1 promoter activity was mediated by dopamine-induced ROS since it was prevented by the hydroxyl radical scavenger N,N"-dimethylthiourea. | Hydroxyl Radical | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 13 | The inhibition of PCMT1 promoter activity was mediated by dopamine-induced ROS since it was prevented by the hydroxyl radical scavenger N,N"-dimethylthiourea. | 1,3-dimethylthiourea | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 14 | Conversely, H2O2 inhibited in a dose-dependent manner the transcriptional activity of PCMT1 promoter. | Hydrogen Peroxide | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 15 | Therefore, our findings identified new molecular mechanisms, cytosolic dopamine and its resulting ROS, as inhibitors of PIMT expression. | Dopamine | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 16 | Therefore, our findings identified new molecular mechanisms, cytosolic dopamine and its resulting ROS, as inhibitors of PIMT expression. | Reactive Oxygen Species | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 17 | This suggests that ROS generated from cytosolic dopamine could reduce both the PCMT1 gene promoter activity and the PIMT protein level thus decreasing its capacity to repair proteins involved in apoptosis and could contribute to neuronal cell death observed in PD. | Reactive Oxygen Species | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 18 | This suggests that ROS generated from cytosolic dopamine could reduce both the PCMT1 gene promoter activity and the PIMT protein level thus decreasing its capacity to repair proteins involved in apoptosis and could contribute to neuronal cell death observed in PD. | Reactive Oxygen Species | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 19 | This suggests that ROS generated from cytosolic dopamine could reduce both the PCMT1 gene promoter activity and the PIMT protein level thus decreasing its capacity to repair proteins involved in apoptosis and could contribute to neuronal cell death observed in PD. | Dopamine | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 20 | This suggests that ROS generated from cytosolic dopamine could reduce both the PCMT1 gene promoter activity and the PIMT protein level thus decreasing its capacity to repair proteins involved in apoptosis and could contribute to neuronal cell death observed in PD. | Dopamine | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |