Title : Molecular ageing of alpha- and Beta-synucleins: protein damage and repair mechanisms.

Pub. Date : 2013

PMID : 23630590






2 Functional Relationships(s)
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Protein Name
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1 Alpha synuclein and beta-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of the repair enzyme protein L-isoaspartyl O-methyltransferase (PIMT). Isoaspartic Acid protein-L-isoaspartate (D-aspartate) O-methyltransferase Homo sapiens
2 The levels of isoaspartate formed over the 20 day time course were quantified by exogenous methylation with PIMT using S-Adenosyl-L-[(3)H-methyl]methionine as a methyl donor, and liquid scintillation counting of liberated (3)H-methanol. Isoaspartic Acid protein-L-isoaspartate (D-aspartate) O-methyltransferase Homo sapiens