Pub. Date : 2013 Mar 18
PMID : 23453623
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Loss of FBP1 induces glycolysis and results in increased glucose uptake, macromolecule biosynthesis, formation of tetrameric PKM2, and maintenance of ATP production under hypoxia. | Glucose | fructose-bisphosphatase 1 | Homo sapiens |
| 2 | Loss of FBP1 induces glycolysis and results in increased glucose uptake, macromolecule biosynthesis, formation of tetrameric PKM2, and maintenance of ATP production under hypoxia. | Adenosine Triphosphate | fructose-bisphosphatase 1 | Homo sapiens |
| 3 | Loss of FBP1 also inhibits oxygen consumption and reactive oxygen species production by suppressing mitochondrial complex I activity; this metabolic reprogramming results in an increased CSC-like property and tumorigenicity by enhancing the interaction of beta-catenin with T-cell factor. | Oxygen | fructose-bisphosphatase 1 | Homo sapiens |
| 4 | Loss of FBP1 also inhibits oxygen consumption and reactive oxygen species production by suppressing mitochondrial complex I activity; this metabolic reprogramming results in an increased CSC-like property and tumorigenicity by enhancing the interaction of beta-catenin with T-cell factor. | Reactive Oxygen Species | fructose-bisphosphatase 1 | Homo sapiens |