Pub. Date : 2013 Feb 4
PMID : 23374508
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107-Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression. | Proline | solute carrier family 10, member 2 | Mus musculus |
| 2 | BACKGROUND: SLC10A2-mediated reabsorption of bile acids at the distal end of the ileum is the first step in enterohepatic circulation. | Bile Acids and Salts | solute carrier family 10, member 2 | Mus musculus |
| 3 | Because bile acids act not only as detergents but also as signaling molecules in lipid metabolism and energy production, SLC10A2 is important as the key transporter for understanding the in vivo kinetics of bile acids. | Bile Acids and Salts | solute carrier family 10, member 2 | Mus musculus |
| 4 | Because bile acids act not only as detergents but also as signaling molecules in lipid metabolism and energy production, SLC10A2 is important as the key transporter for understanding the in vivo kinetics of bile acids. | Bile Acids and Salts | solute carrier family 10, member 2 | Mus musculus |
| 5 | In this study, proline and uncharged polar residues in the remaining two-thirds of this region in mouse Slc10a2 were subjected to mutational analysis, and taurocholic acid uptake and cell surface localization were examined. | Proline | solute carrier family 10, member 2 | Mus musculus |
| 6 | Cell surface localization of Slc10a2 is necessary for bile acid absorption. | Bile Acids and Salts | solute carrier family 10, member 2 | Mus musculus |
| 7 | CONCLUSIONS: The functional importance of proline and uncharged polar residues in the highly conserved region of mouse Slc10a2 was determined. | Proline | solute carrier family 10, member 2 | Mus musculus |
| 8 | This information will contribute to the design of bile acid-conjugated prodrugs for efficient drug delivery or SLC10A2 inhibitors for hypercholesterolemia treatment. | Bile Acids and Salts | solute carrier family 10, member 2 | Mus musculus |