Title : Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat.

Pub. Date : 2012 Nov

PMID : 22998629






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Loss of CYP46A1-expressing retinal ganglion cells is involved in the activation of glia, and therefore possibly in the disbalance of cholesterol. Cholesterol cytochrome P450, family 46, subfamily a, polypeptide 1 Rattus norvegicus
2 CONCLUSIONS: These data show that CYP46A1 expression was induced early in response to retinal stress but remained constant at late time-points, reinforcing the constitutive role of CYP46A1 in maintaining cholesterol balance in neuronal tissues. Cholesterol cytochrome P450, family 46, subfamily a, polypeptide 1 Rattus norvegicus