Title : Implication of C-type natriuretic peptide-3 signaling in glycosaminoglycan synthesis and chondrocyte hypertrophy during TGF-β1 induced chondrogenic differentiation of chicken bone marrow-derived mesenchymal stem cells.

Pub. Date : 2012 Oct

PMID : 22714108






3 Functional Relationships(s)
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1 In pellet cultures of MSCs, TGF-beta1 successfully induced chondrogenic differentiation and glycosaminoglycan synthesis. Glycosaminoglycans transforming growth factor beta 1 Gallus gallus
2 Addition of CNP into the TGF-beta1 supplemented chondrogenic differentiation medium further induced the glycosaminoglycan synthesis and hypertrophy of differentiated chondrocytes in these pellets. Glycosaminoglycans transforming growth factor beta 1 Gallus gallus
3 Pellets induced with TGF-beta1 and treated with antibodies against CNP and NPR-B, did show collagen type II expression, however, Alcian blue staining showing glycosaminoglycan synthesis was significantly suppressed. Alcian Blue transforming growth factor beta 1 Gallus gallus