Pub. Date : 2012 Nov
PMID : 22624680
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY RESULTS: NA-5HT completely inhibited Ca(V) 3 channels with a rank order of potency (pEC(50) ) of Ca(V) 3.1 (7.4) > Ca(V) 3.3 (6.8) >= Ca(V) 3.2 (6.6). | na-5ht | carbonic anhydrase 5A | Homo sapiens |
| 2 | KEY RESULTS: NA-5HT completely inhibited Ca(V) 3 channels with a rank order of potency (pEC(50) ) of Ca(V) 3.1 (7.4) > Ca(V) 3.3 (6.8) >= Ca(V) 3.2 (6.6). | na-5ht | carbonic anhydrase 5A | Homo sapiens |
| 3 | The effects of NA-5HT were voltage-dependent, and it produced significant hyperpolarizing shifts in Ca(V) 3 steady-state inactivation relationships. | na-5ht | carbonic anhydrase 5A | Homo sapiens |
| 4 | NA-5HT selectively affected Ca(V) 3.3 channel kinetics. | na-5ht | carbonic anhydrase 5A | Homo sapiens |
| 5 | CONCLUSIONS AND IMPLICATIONS: NA-5HT increases the steady-state inactivation of Ca(V) 3 channels, reducing the number of channels available to open during depolarization. | na-5ht | carbonic anhydrase 5A | Homo sapiens |