Pub. Date : 2011 Sep 7
PMID : 21907141
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A SPAK isoform switch modulates renal salt transport and blood pressure. | Salts | serine/threonine kinase 39 | Mus musculus |
| 2 | An emerging model suggests that bumetanide- and thiazide-sensitive NaCl transporters (NKCC2 and NCC) along these segments are phosphorylated and activated by WNK kinases, via SPAK and OSR1. | Bumetanide | serine/threonine kinase 39 | Mus musculus |
| 3 | In mice, extracellular fluid volume depletion shifts SPAK isoform abundance to favor NaCl retention along both segments, indicating that a SPAK isoform switch modulates sodium avidity along the distal nephron. | Sodium Chloride | serine/threonine kinase 39 | Mus musculus |
| 4 | In mice, extracellular fluid volume depletion shifts SPAK isoform abundance to favor NaCl retention along both segments, indicating that a SPAK isoform switch modulates sodium avidity along the distal nephron. | Sodium | serine/threonine kinase 39 | Mus musculus |