Pub. Date : 2010 Apr 12
PMID : 20404936
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODOLOGY/PRINCIPAL FINDINGS: PB activation of nuclear xenobiotic receptor CAR is found to induce the Gadd45b gene in mouse liver throughout the development of HCC as well as in liver tumors. | Phenobarbital | growth arrest and DNA-damage-inducible 45 beta | Mus musculus |
| 2 | The present finding that CAR can repress cell death via its interaction with GADD45B provides an insight for further investigations into the CAR-regulated molecular mechanism by which PB promotes development of HCC. | Phenobarbital | growth arrest and DNA-damage-inducible 45 beta | Mus musculus |