Pub. Date : 2007 Nov-Dec
PMID : 17659913
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Myeloid enriched BM cells from gadd45a and gadd45b deficient mice were observed to be more sensitive to ultraviolet radiation (UVC), VP-16, and daunorubicin (DNR)-induced apoptosis compared to wild-type (wt) cells. | Etoposide | growth arrest and DNA-damage-inducible 45 beta | Mus musculus |
| 2 | Myeloid enriched BM cells from gadd45a and gadd45b deficient mice were observed to be more sensitive to ultraviolet radiation (UVC), VP-16, and daunorubicin (DNR)-induced apoptosis compared to wild-type (wt) cells. | Daunorubicin | growth arrest and DNA-damage-inducible 45 beta | Mus musculus |
| 3 | Both gadd45a and gadd45b deficient BM cells also displayed defective G2/M arrest following exposure to UVC and VP-16, but not to DNR, indicating the existence of different G2/M checkpoints that are either dependent or independent of gadd45. | Etoposide | growth arrest and DNA-damage-inducible 45 beta | Mus musculus |
| 4 | These observations set the stage to evaluate, in clinically relevant settings, the impact that the status of gadd45a and gadd45b might have on the efficacy of DNR or VP-16 in killing leukemic cells. | Etoposide | growth arrest and DNA-damage-inducible 45 beta | Mus musculus |