Title : Effects of vanadate on hepatic cytochrome P-450 expression in streptozotocin-diabetic rats.

Pub. Date : 1990 Jul-Aug

PMID : 1698138






3 Functional Relationships(s)
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1 Streptozotocin caused P-450h levels to fall 95%, and P-450j and P-450b levels to rise 8- and 40-fold, respectively, after 1 week. Streptozocin cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 When diabetic rats were administered metavanadate in the drinking water for 7 days, P-450h apoprotein and mRNA levels remained no different from those of untreated diabetic rats, whereas levels of P-450b and P-450j decreased toward those of control rats. Vanadates cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
3 When diabetic rats were administered metavanadate in the drinking water for 7 days, P-450h apoprotein and mRNA levels remained no different from those of untreated diabetic rats, whereas levels of P-450b and P-450j decreased toward those of control rats. Drinking Water cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus