Pub. Date : 2007 Apr
PMID : 16675063
12 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
2 | Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
3 | Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
4 | Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
5 | Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
6 | Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
7 | Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
8 | Treatment of TgCRND8 mice with Tramiprosate resulted in significant reduction (approximately 30%) in the brain amyloid plaque load and a significant decrease in the cerebral levels of soluble and insoluble Abeta(40) and Abeta(42) (approximately 20-30%). | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
9 | Treatment of TgCRND8 mice with Tramiprosate resulted in significant reduction (approximately 30%) in the brain amyloid plaque load and a significant decrease in the cerebral levels of soluble and insoluble Abeta(40) and Abeta(42) (approximately 20-30%). | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
10 | A dose-dependent reduction (up to 60%) of plasma Abeta levels was also observed, suggesting that Tramiprosate influences the central pool of Abeta, changing either its efflux or its metabolism in the brain. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
11 | A dose-dependent reduction (up to 60%) of plasma Abeta levels was also observed, suggesting that Tramiprosate influences the central pool of Abeta, changing either its efflux or its metabolism in the brain. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus | ||
12 | We propose that Tramiprosate, which targets soluble Abeta, represents a new and promising therapeutic class of drugs for the treatment of AD. | tramiprosate | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |