Title : Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis.

Pub. Date : 2007 Apr

PMID : 16675063






12 Functional Relationships(s)
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1 Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
2 Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
3 Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
4 Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
5 Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
6 Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
7 Among a series of ionic compounds able to interact with soluble Abeta, Tramiprosate (3-amino-1-propanesulfonic acid; 3APS; Alzhemedtrade mark) was found to maintain Abeta in a non-fibrillar form, to decrease Abeta(42)-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
8 Treatment of TgCRND8 mice with Tramiprosate resulted in significant reduction (approximately 30%) in the brain amyloid plaque load and a significant decrease in the cerebral levels of soluble and insoluble Abeta(40) and Abeta(42) (approximately 20-30%). tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
9 Treatment of TgCRND8 mice with Tramiprosate resulted in significant reduction (approximately 30%) in the brain amyloid plaque load and a significant decrease in the cerebral levels of soluble and insoluble Abeta(40) and Abeta(42) (approximately 20-30%). tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
10 A dose-dependent reduction (up to 60%) of plasma Abeta levels was also observed, suggesting that Tramiprosate influences the central pool of Abeta, changing either its efflux or its metabolism in the brain. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
11 A dose-dependent reduction (up to 60%) of plasma Abeta levels was also observed, suggesting that Tramiprosate influences the central pool of Abeta, changing either its efflux or its metabolism in the brain. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus
12 We propose that Tramiprosate, which targets soluble Abeta, represents a new and promising therapeutic class of drugs for the treatment of AD. tramiprosate histocompatibility 2, class II antigen A, beta 1 Mus musculus