Title : The ileocyte basolateral organic solute transporter (OSTalpha-OSTbeta) complex: finding the missing link in enterohepatic circulation.

Pub. Date : 2005 Feb

PMID : 15731499






4 Functional Relationships(s)
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1 Bile acids are transported across the ileocyte apical (brush border) membrane by the apical sodium-dependent bile-acid transporter (Asbt), but the identity of the primary transporter responsible for moving bile acids across the basolateral membrane of the ileocyte has remained a mystery, although not for a lack of protein pretenders to the throne. Bile Acids and Salts solute carrier family 10, member 2 Mus musculus
2 Bile acids are transported across the ileocyte apical (brush border) membrane by the apical sodium-dependent bile-acid transporter (Asbt), but the identity of the primary transporter responsible for moving bile acids across the basolateral membrane of the ileocyte has remained a mystery, although not for a lack of protein pretenders to the throne. Bile Acids and Salts solute carrier family 10, member 2 Mus musculus
3 Bile acids are transported across the ileocyte apical (brush border) membrane by the apical sodium-dependent bile-acid transporter (Asbt), but the identity of the primary transporter responsible for moving bile acids across the basolateral membrane of the ileocyte has remained a mystery, although not for a lack of protein pretenders to the throne. Bile Acids and Salts solute carrier family 10, member 2 Mus musculus
4 Recent insights from transcriptional profiling studies of wild-type and Asbt-deficient mice indicate that a complex formed by the organic solute carrier proteins alpha and beta (Ostalpha and Ostbeta) is the primary transporter for basolateral bile acid transport. Bile Acids and Salts solute carrier family 10, member 2 Mus musculus