Title : A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion.

Pub. Date : 2004 Apr 15

PMID : 14976163






1 Functional Relationships(s)
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1 In contrast to human patients, Atp8b1(G308V/G308V) mice had unimpaired bile secretion and no liver damage, but showed mild abnormalities including depressed weight at weaning and elevated serum bile salt levels. Bile Acids and Salts ATPase phospholipid transporting 8B1 Homo sapiens