Title : Hemin: a possible cause of oxidative stress in blood circulation of beta-thalassemia/hemoglobin E disease.

Pub. Date : 2003 Feb

PMID : 12653201






4 Functional Relationships(s)
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1 Pro-oxidant activity in serum of beta-thal/Hb E was demonstrated by luminol-mediated chemiluminescence, a sensitive method for screening of free radical generation in vitro. Luminol hemoglobin subunit epsilon 1 Homo sapiens
2 Pro-oxidant activity in serum of beta-thal/Hb E was demonstrated by luminol-mediated chemiluminescence, a sensitive method for screening of free radical generation in vitro. Free Radicals hemoglobin subunit epsilon 1 Homo sapiens
3 In the presence of H2O2, the chemiluminescence intensity (CL) was about 20 fold enhanced in serum of beta-thal/Hb E, indicating its extensive pro-oxidant activity. Hydrogen Peroxide hemoglobin subunit epsilon 1 Homo sapiens
4 Our finding suggested that serum hemin readily catalyzed free radical reactions and it may contribute a major pro-oxidant in blood circulation of beta-thal/Hb E. Hemin hemoglobin subunit epsilon 1 Homo sapiens