Title : C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells.

Pub. Date : 1998 Nov 26

PMID : 9840945






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells. Tyrosine Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus
2 Adhesion of both normal and transformed cells to fibronectin or other extracellular matrix proteins consistently induces the tyrosine-phosphorylation of C3G. Tyrosine Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus
3 Adhesion-induced tyrosine phosphorylation of C3G is dependent on an intact cytoskeleton and peaks at 5-10 min after attachment. Tyrosine Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus
4 These data establish that integrin-mediated cell adhesion results in Crkl-mediated tyrosine phosphorylation of C3G, a pathway which can be disrupted by Bcr/Abl. Tyrosine Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus