Title : Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis.

Pub. Date : 1998 Nov 1

PMID : 9802881






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Flavopiridol inhibits most cyclin-dependent kinases (cdks) and displays unique anticancer properties. alvocidib cyclin dependent kinase 1 Homo sapiens
2 Exposure of HNSCC cells to flavopiridol diminished cdc2 and cdk2 activity and potently inhibited cell proliferation (IC50 43-83 nM), which was concomitant with the appearance of cells with a sub-G1 DNA content. alvocidib cyclin dependent kinase 1 Homo sapiens