Pub. Date : 1998 Oct
PMID : 9751175
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-1 beta and tumor necrosis factor-alpha suppress dexamethasone induction of glutamine synthetase in primary mouse astrocytes. | Dexamethasone | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |
| 2 | As the glucocorticoid receptor has been shown to interact with transcription factors that may also be activated by the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), we hypothesized that IL-1beta or TNF-alpha might oppose the induction of glutamine synthetase by dexamethasone. | Dexamethasone | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |
| 3 | We found that both cytokines attenuated the dexamethasone induction of glutamine synthetase protein at 24 h and that the effect was dose-dependent. | Dexamethasone | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |
| 4 | We also found that IL-1beta and TNF-alpha inhibited the induction of glutamine synthetase mRNA by dexamethasone, and that the induction of enzymatic activity was similarly prevented by IL-1beta. | Dexamethasone | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |