Title : Mechanism of factor IXa inhibition by antithrombin in the presence of unfractionated and low molecular weight heparins and fucoidan.

Pub. Date : 1998 Sep 8

PMID : 9748565






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The aim of this study was to compare the catalysis of inhibition of blood fIXa by antithrombin in the presence of several sulfated polysaccharides with anticoagulant activity, i.e. heparin, three widely used in therapeutics low molecular weight heparins (LMWH) and fucoidan. Heparin, Low-Molecular-Weight serpin family C member 1 Homo sapiens
2 Plots of the second-order rate constants of the fIXa-antithrombin reaction vs. the concentration of added heparin and LMWH are bell-shaped and fit the kinetic model established for thrombin-antithrombin reaction by Jordan R., Beeler D., Rosenberg R. (1979) J. Biol. Heparin, Low-Molecular-Weight serpin family C member 1 Homo sapiens
3 Plots of the second-order rate constants of the fIXa-antithrombin reaction vs. the concentration of added heparin and LMWH are bell-shaped and fit the kinetic model established for thrombin-antithrombin reaction by Jordan R., Beeler D., Rosenberg R. (1979) J. Biol. Heparin, Low-Molecular-Weight serpin family C member 1 Homo sapiens