Title : G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils.

Pub. Date : 1997 Dec 15

PMID : 9704065






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 PI 3-kinase activity in untreated cells is bimodal showing a maximum production after 10-15 sec that protracts with a lower PIP3 formation for approximately 2 min and returns to basal levels after 2-3 min. PIP3 Phosphatidylinositol 3-kinase 92E Drosophila melanogaster
2 The present observations suggest that in phagocytes stimulated with agonists of G-protein-coupled receptors the bulk of PIP3 is generated by PI 3-kinase alpha, which is activated through a genistein-sensitive target, presumably a protein tyrosine kinase. PIP3 Phosphatidylinositol 3-kinase 92E Drosophila melanogaster