Title : Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site.

Pub. Date : 1998 Jul 28

PMID : 9692954






1 Functional Relationships(s)
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1 Homology modeling of PEDF based on the X-ray crystal structures of antithrombin III and ovalbumin shows a region at the center of beta-sheet A-strands 2 and 3- and helix F that has a basic electrostatic surface potential and is densely populated with lysines exposed to the surface (K134, K137, K189, K191, H212, and K214) that are available to interact with various glycosaminoglycans/polyanions. Glycosaminoglycans serpin family C member 1 Homo sapiens