Title : Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme.

Pub. Date : 1998 Aug 1

PMID : 9677309






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Methylglyoxal-bis(guanylhydrazone) (MGBG), a potent inhibitor of human AdoMetDC, was a poor inhibitor of the T. cruzi enzyme. Mitoguazone adenosylmethionine decarboxylase 1 Homo sapiens
2 Methylglyoxal-bis(guanylhydrazone) (MGBG), a potent inhibitor of human AdoMetDC, was a poor inhibitor of the T. cruzi enzyme. Mitoguazone adenosylmethionine decarboxylase 1 Homo sapiens
3 This differential sensitivity to MGBG suggests that the two enzymes are sufficiently different to warrant the search for compounds that might interfere with the progression of Chagas" disease by selectively inhibiting T. cruzi AdoMetDC. Mitoguazone adenosylmethionine decarboxylase 1 Homo sapiens