Title : Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox).

Pub. Date : 1998 Jul 3

PMID : 9642219






3 Functional Relationships(s)
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1 Superoxide generation by the neutrophil respiratory burst oxidase (NADPH oxidase) can be reconstituted in a cell-free system using flavocytochrome b558 and the cytosolic proteins p47(phox), p67(phox), and Rac. Superoxides CD33 molecule Homo sapiens
2 In the presence of wild-type p67(phox), the V204A mutant was a potent inhibitor of superoxide generation, and inhibition was partially reversed by high concentrations of p67(phox), but not by p47(phox) or Rac. Superoxides CD33 molecule Homo sapiens
3 In the presence of wild-type p67(phox), the V204A mutant was a potent inhibitor of superoxide generation, and inhibition was partially reversed by high concentrations of p67(phox), but not by p47(phox) or Rac. Superoxides CD33 molecule Homo sapiens