Title : Novel C5a receptor antagonists regulate neutrophil functions in vitro and in vivo.

Pub. Date : 1998 Jun 1

PMID : 9605167






1 Functional Relationships(s)
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1 Additionally, CSaRAM and CSaRAD inhibited binding of 125I-labeled recombinant human C5a to neutrophil membranes (Ki = 79 and 2 pM, respectively), C5a-stimulated neutrophil intracellular calcium mobilization (8 and 13 nM), CD11b integrin up-regulation (10 and 1 nM), superoxide generation (182 and 282 nM), lysozyme release (1 and 2 microM), and chemotaxis (11 and 7 microM). Superoxides complement C5a receptor 1 Homo sapiens