Title : Effect of vitamin D3 on interleukin-6 synthesis induced by prostaglandins in osteoblasts.

Pub. Date : 1998 Feb

PMID : 9578149






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1 Effect of vitamin D3 on interleukin-6 synthesis induced by prostaglandins in osteoblasts. Cholecalciferol interleukin 6 Mus musculus
2 In the present study, we investigated the effect of vitamin D3 on IL-6 synthesis in MC3T3-E1 cells. Cholecalciferol interleukin 6 Mus musculus
3 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), an active form of vitamin D3, inhibited the IL-6 synthesis induced by PGF2alpha or PGE1. Cholecalciferol interleukin 6 Mus musculus
4 These results strongly suggest that 1,25-(OH)2D3, an active form of vitamin D3, inhibits IL-6 synthesis at both the protein kinase C pathway and the protein kinase A pathway in osteoblasts. Cholecalciferol interleukin 6 Mus musculus