Title : Desmopressin and low-dose ACTH test in rheumatoid arthritis.

Pub. Date : 1998 Mar

PMID : 9539304






3 Functional Relationships(s)
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1 After low-dose ACTH, a similar significant (P < 0.01) cortisol response was found in both RA patients and controls; indeed in RA patients DHEA AUC (2196.0 +/- 321.8 nmol/l per 90 min) was significantly lower (P < 0.01) than DHEA AUC (4280.8 +/- 749.0 nmol/l per 90 min) in controls. Dehydroepiandrosterone proopiomelanocortin Homo sapiens
2 After low-dose ACTH, a similar significant (P < 0.01) cortisol response was found in both RA patients and controls; indeed in RA patients DHEA AUC (2196.0 +/- 321.8 nmol/l per 90 min) was significantly lower (P < 0.01) than DHEA AUC (4280.8 +/- 749.0 nmol/l per 90 min) in controls. Dehydroepiandrosterone proopiomelanocortin Homo sapiens
3 The reduced basal and low-dose ACTH-induced DHEA levels could reflect both a reduced sensitivity of the adrenal gland to exogenous corticotropin and a decreased steroid synthesis due to a partial adrenal enzymatic defect (P450 17,20 lyase). Dehydroepiandrosterone proopiomelanocortin Homo sapiens