Title : Conformation and unfolding thermodynamics of epidermal growth factor and derivatives.

Pub. Date : 1976 Jun 15

PMID : 938633






2 Functional Relationships(s)
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1 From these thermodynamic parameters one can calculate that the large reduction in delta G degrees due to scission of the single peptide bond between residues 21 and 22 can be attributed almost completely to a change in entropy; e.g., at 40 degrees C the apparent entropy of unfolding of EGF is 20.4 cal mol-1 deg-1 while that of the cyanogen bromide derivative is 66.4 cal mol-1 deg-1. Cyanogen Bromide modifier of LPS-response 1 Mus musculus
2 From these thermodynamic parameters one can calculate that the large reduction in delta G degrees due to scission of the single peptide bond between residues 21 and 22 can be attributed almost completely to a change in entropy; e.g., at 40 degrees C the apparent entropy of unfolding of EGF is 20.4 cal mol-1 deg-1 while that of the cyanogen bromide derivative is 66.4 cal mol-1 deg-1. Cyanogen Bromide modifier of LPS-response 1 Mus musculus