Title : The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells.

Pub. Date : 1997 Nov 15

PMID : 9371520






1 Functional Relationships(s)
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1 We found that the signal generated by the DNA damage checkpoint in G2 was dominant over that from the spindle microtubule-assembly checkpoint, because the high Cdc2 activity present in nocodazole or Taxol-arrested cells was reduced by DNA damage. Nocodazole cyclin dependent kinase 1 Homo sapiens