Title : Glycosaminoglycans mediate cell surface oligomerization of chemokines.

Pub. Date : 1997 Nov 4

PMID : 9354625






2 Functional Relationships(s)
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1 The endothelial cell binding sites for IL-8, RANTES, and MCP-1 were deduced to be glycosaminoglycans since competition assays showed the biphasic curves and micromolar IC50 values seen in studies with immobilized heparin, and mRNA for known chemokine receptors was not detected. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens
2 Removal of glycosaminoglycans from CHO cells expressing chemokine receptors CXCR1, CCR1, or CCR2 resulted in 40-70% decreases in the binding of RANTES, MCP-1, IL-8, and MIP-1alpha. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens