Title : Inhibition of meizothrombin and meizothrombin(desF1) by heparin cofactor II.

Pub. Date : 1997 Nov 7

PMID : 9353333






2 Functional Relationships(s)
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1 Purified recombinant meizothrombin and meizothrombin(desF1) were inhibited by HCII in the presence of dermatan sulfate with maximal second-order rate constants of 8 x 10(6) M-1.min-1 and 1.8 x 10(7) M-1.min-1, respectively, but were inhibited less than one-tenth as fast by AT in the presence of heparin. Dermatan Sulfate serpin family D member 1 Homo sapiens
2 When HCII and dermatan sulfate were present continuously during the prothrombinase reaction, meizothrombin was trapped as a sodium dodecyl sulfate-stable complex with HCII and no amidolytic activity could be detected with a thrombin substrate. Dermatan Sulfate serpin family D member 1 Homo sapiens