Title : Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells.

Pub. Date : 1997 Aug 1

PMID : 9260897






1 Functional Relationships(s)
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1 RA did not affect cyclins D1, A, and E and cyclin-dependent kinase 2 (CDK2) expression, but significantly reduced cyclin D3 and CDK4 expression after 24 h. RA also inhibited cyclin B1 and CDC2 expression, possibly responsible for the reduction of the proportion of cells in G2 + M and S phases. Tretinoin cyclin dependent kinase 1 Homo sapiens