Title : Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2.

Pub. Date : 1997 Aug 19

PMID : 9254595






1 Functional Relationships(s)
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1 Interaction of the Shc-derived phosphotyrosine hexapeptide Ac-SpYVNVQ-NH2 with Grb2-SH2 was both enthalpically and entropically favorable (DeltaH = -7.55 kcal mol-1, -TDeltaS = -1.46 kcal mol-1 , DeltaG = -9.01 kcal mol-1, T = 20 degrees C). Amido radical growth factor receptor bound protein 2 Homo sapiens