Pub. Date : 1997 Feb 15
PMID : 9078249
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calcium-dependence of synexin binding may determine aggregation and fusion of lamellar bodies. | Calcium | annexin A7 | Homo sapiens |
| 2 | Synexin (annexin VII) is a member of the annexin family of calcium and phospholipid binding proteins that promote calcium-dependent aggregation and fusion of lipid vesicles or secretory granules. | Calcium | annexin A7 | Homo sapiens |
| 3 | Synexin (annexin VII) is a member of the annexin family of calcium and phospholipid binding proteins that promote calcium-dependent aggregation and fusion of lipid vesicles or secretory granules. | Calcium | annexin A7 | Homo sapiens |
| 4 | Synexin (annexin VII) is a member of the annexin family of calcium and phospholipid binding proteins that promote calcium-dependent aggregation and fusion of lipid vesicles or secretory granules. | Calcium | annexin A7 | Homo sapiens |
| 5 | Synexin (annexin VII) is a member of the annexin family of calcium and phospholipid binding proteins that promote calcium-dependent aggregation and fusion of lipid vesicles or secretory granules. | Calcium | annexin A7 | Homo sapiens |
| 6 | In this study, we characterized calcium-dependency of synexin binding to lamellar bodies and plasma membranes, since such binding is the initial, and, therefore, may be the rate-limiting step in membrane aggregation and fusion. | Calcium | annexin A7 | Homo sapiens |
| 7 | The binding of biotinylated synexin to lamellar bodies and plasma membranes increased in a calcium-dependent manner reaching a maximum at approx. | Calcium | annexin A7 | Homo sapiens |
| 8 | The calcium kinetics were noticeably similar for synexin binding to lamellar bodies and plasma membranes, aggregation of lamellar bodies, and fusion of lamellar bodies with lipid vesicles. | Calcium | annexin A7 | Homo sapiens |
| 9 | At low calcium concentrations, aggregation of lamellar bodies could be increased with increasing synexin concentration, and arachidonic acid increased all three parameters (binding, aggregation, and fusion) in a similar manner. | Calcium | annexin A7 | Homo sapiens |
| 10 | The effects of calcium and arachidonic acid on these three parameters suggest that synexin binding to lamellar bodies may be a rate-determining step for fusion during surfactant secretion. | Calcium | annexin A7 | Homo sapiens |
| 11 | Furthermore, at near physiological calcium levels, the membrane fusion may be enhanced by elevated concentrations of synexin and polyunsaturated fatty acids. | Calcium | annexin A7 | Homo sapiens |