Title : Acute effects of bromocriptine, cyproheptadine, and valproic acid on plasma adrenocorticotropin secretion in Nelson's syndrome.

Pub. Date : 1997 Feb

PMID : 9024246






3 Functional Relationships(s)
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1 Previous studies have found that bromocriptine, cyproheptadine, and valproic acid can reduce ACTH secretion in Nelson"s syndrome, but none of these agents has achieved widespread use due to their failure to normalize ACTH in most patients. Bromocriptine proopiomelanocortin Homo sapiens
2 Bromocriptine, on the other hand, caused a significant decrease in plasma ACTH (52 +/- 8%; P < 0.05), as did the combination of bromocriptine, cyproheptadine, and valproic acid (58 +/- 12%; P < 0.05). Bromocriptine proopiomelanocortin Homo sapiens
3 We conclude that at the doses studied, bromocriptine had the greatest acute effect in suppressing ACTH secretion in Nelson"s syndrome, and that combined administration with valproic acid and cyproheptadine did not further increase this acute ACTH-suppressive effect. Bromocriptine proopiomelanocortin Homo sapiens