Title : Ethanol microinjection into the area postrema selectively attenuates baroreflex sensitivity measured by vasopressin in conscious rats.

Pub. Date : 1996 Dec 6

PMID : 8977137






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1 Ethanol microinjection into the area postrema selectively attenuates baroreflex sensitivity measured by vasopressin in conscious rats. Ethanol arginine vasopressin Rattus norvegicus
2 Microinjection of ethanol (10 microg) into the area postrema (AP) of conscious rats attenuated baroreflex sensitivity (BRS) measured by arginine vasopressin (AVP) (-1.73 +/- 0.13 versus -2.47 +/- 0.16 bpm/mmHg), but not by phenylephrine (PE) (-1.94 +/- 0.26 versus -1.82 +/- 0.20 bpm/mmHg). Ethanol arginine vasopressin Rattus norvegicus
3 Microinjection of ethanol (10 microg) into the area postrema (AP) of conscious rats attenuated baroreflex sensitivity (BRS) measured by arginine vasopressin (AVP) (-1.73 +/- 0.13 versus -2.47 +/- 0.16 bpm/mmHg), but not by phenylephrine (PE) (-1.94 +/- 0.26 versus -1.82 +/- 0.20 bpm/mmHg). Ethanol arginine vasopressin Rattus norvegicus
4 Intra-AP injection of the V1 receptor antagonist D(CH2)5Tyr(Me)AVP replicated the differential effects of ethanol on BRS measured by AVP (-1.89 +/- 0.11 versus -2.52 +/- 0.10 bpm/mmHg) and PE (-2.10 +/- 0.12 versus -2.09 +/- 0.19 bpm/mmHg). Ethanol arginine vasopressin Rattus norvegicus
5 Intra-AP injection of the V1 receptor antagonist D(CH2)5Tyr(Me)AVP replicated the differential effects of ethanol on BRS measured by AVP (-1.89 +/- 0.11 versus -2.52 +/- 0.10 bpm/mmHg) and PE (-2.10 +/- 0.12 versus -2.09 +/- 0.19 bpm/mmHg). Ethanol arginine vasopressin Rattus norvegicus
6 These data suggest that ethanol attenuates the facilitatory action of AVP on baroreflexes via its interaction with AVP neurons in the AP. Ethanol arginine vasopressin Rattus norvegicus
7 These data suggest that ethanol attenuates the facilitatory action of AVP on baroreflexes via its interaction with AVP neurons in the AP. Ethanol arginine vasopressin Rattus norvegicus