Title : Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes.

Pub. Date : 1996 Nov 1

PMID : 8914854






1 Functional Relationships(s)
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1 Upon reconstitution with P450 reductase and cytochrome b5, CYP4A11 proved to be a potent laurate omega-hydroxylase, exhibiting a turnover rate of 45.7 nmol 12-hydroxylaurate formed/min/nmol P450 (12-fold greater than intact microsomes), while catalyzing the omega-1 hydroxylation reaction at much lower rates (5.4 nmol 11-hydroxylaurate formed/min/nmol P450). 12-hydroxylaurate cytochrome P450 family 4 subfamily A member 11 Homo sapiens