Title : Antidepressant drug interactions and the cytochrome P450 system. The role of cytochrome P450 2D6.

Pub. Date : 1995

PMID : 8846618






2 Functional Relationships(s)
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1 The selective serotonin reuptake inhibitors (SSRIs) and venlafaxine display the following rank order of in vitro potency against the cytochrome P450 (CYP) isoenzyme CYP2D6 as measured by their inhibition sparteine and/or dextromethorphan metabolism: paroxetine > fluoxetine identical to norfluoxetine > or = sertraline > or = fluvoxamine > venlafaxine. Fluvoxamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 The selective serotonin reuptake inhibitors (SSRIs) and venlafaxine display the following rank order of in vitro potency against the cytochrome P450 (CYP) isoenzyme CYP2D6 as measured by their inhibition sparteine and/or dextromethorphan metabolism: paroxetine > fluoxetine identical to norfluoxetine > or = sertraline > or = fluvoxamine > venlafaxine. Fluvoxamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens