Title : Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme.

Pub. Date : 1996 May 17

PMID : 8662659






1 Functional Relationships(s)
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Protein Name
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1 Clones expressing elevated human (386-5938 milliunits/mg) or rat (4-597 milliunits/mg, benzaldehyde/NADP+ substrate) ALDH-3 activity were 1.3- to 12-fold resistant to mafosfamide relative to control cells (<1 milliunit/mg). benzaldehyde aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus