Title : The regulation of neutrophil phospholipase A2 by granulocyte-macrophage colony-stimulating factor and its role in priming superoxide production.

Pub. Date : 1996 Mar

PMID : 8616070






3 Functional Relationships(s)
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1 The regulation of neutrophil phospholipase A2 by granulocyte-macrophage colony-stimulating factor and its role in priming superoxide production. Superoxides colony stimulating factor 2 Homo sapiens
2 In cells preincubated with GM-CSF, time- and dose-dependent priming of FMLP-stimulated PLA2 responses were observed and inhibition of PLA2 by mepacrine was accompanied by the inhibition of FMLP-stimulated superoxide production down to the level of unprimed cells. Superoxides colony stimulating factor 2 Homo sapiens
3 These data suggest that a mepacrine-sensitive PLA2 may have a role in the GM-CSF mediated priming of superoxide production. Superoxides colony stimulating factor 2 Homo sapiens