Title : Cholesterol-independent membrane disruption caused by triterpenoid saponins.

Pub. Date : 1996 Jan 19

PMID : 8555271






2 Functional Relationships(s)
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1 Namely, the saponins could induce a permeability change on liposomal membrane without cholesterol when they are glycosylated at both C-3 and C-28 of the oleanolic acid. Saponins complement C3 Homo sapiens
2 The saponins glycosylated only at C-3 could also exhibit the same activity with somewhat different action profiles when the glucuronic acid is esterified, while those with the free glucuronic acid required cholesterol in the liposomes to induce permeability change thereof. Saponins complement C3 Homo sapiens